Pharma Concept
Modular freeze drying systems especially for cGMP production
Details
Our Zeta series is a range of steam sterilizable freeze dryers with loading and unloading systems specifically designed for cGMP pharmaceutical production. The series covers production sizes from 1 to 13 m². The compact models, including loading system and optional PAT tools, can be fully integrated into a filling line with containment system.
The standardized Zeta freeze drying system enables fast, cost-effective and uncomplicated project implementation. The modular design enables individual solutions.
Models & data
Our preconfigured freeze drying systems are available in six different sizes:
| Model | Zeta-1 | Zeta-2 | Zeta-4 | Zeta-6 | Zeta-10 | Zeta-13 | |
|---|---|---|---|---|---|---|---|
| Max. shelves (m²) | 1.1 | 2.2 | 4.1 | 5.8 | 10 | 13 | |
| Number of shelves | 2 - 5 | 4 - 6 | 5 - 8 | 6 - 8 | 6 - 10 | 7 - 9 | |
| Shef dimensions (W x D) in mm | 500 x 450 | 600 x 600 | 600 x 850 | 850 x 850 | 850 x 1,200 | 1,200 x 1,200 | |
| Ice capacity (kg) | 12 | 24 | 45 | 63 | 111 | 141 | |
| Batch volume (ca. in l)* | 7.8 | 15.2 | 29.0 | 40.8 | 72.8 | 94.0 | |
| Max. number of 2R vials | 4,880 | 9,546 | 18,056 | 25,624 | 45,150 | 57,663 | |
| Max. number of 10R vials | 2,100 | 4,116 | 7,840 | 11,040 | 19,670 | 25,398 |
Notes: Subject to technical changes / * Batch volume: for 10R vials and 1 cm filling volume
Process optimization
Use our comprehensive process monitoring for your own quality assurance and documentation. Our Process Analytical Technologies (PAT) lead to an understanding of the complex processes and enable stable drying processes.
Camera system
LyoCam
Video recordings of the product at variable intervals, depending on the process steps or as event-controlled recording – LyoCam brings greater transparency to the freeze drying process. Monitoring and analysis of freeze drying is easy and uncomplicated with this technology from Martin Christ.
- High-end full HD industrial camera
- Cold light LED lamps to avoid energy input
- Completely integrated with LPCplus process visualization
- Intelligent image storage, with image frequency linked to special process events
- Identical timestamp to other logged process parameters
- Up to four cameras can be used in LPCplus
- Observation of loading, unloading and vial closure processes
Controlled Nucleation
LyoCoN
Precision freezing of all vials – that is the controlled nucleation solution LyoCoN from Martin Christ. At the press of a button, crystallization of all the vials in the freeze dryer is initiated.
- Ice vapour is generated from the product, so no additional external substances (such as WFI) are required
- GMP compliant process
- No media (exhaust air or gas) that could contain active substances or product to be treated
Wireless product temperature measurement
WTMplus
The wireless product temperature measurement system WTMplus from Martin Christ makes wireless sensor-based product temperature measurement possible for freeze drying. Wireless sensors are placed direclty in the vials during loading and report product temperatures to the system controller during the entire drying process.
- Low influence of product temperature due to passive construction without batteries and very low power levels
- Power supply to the temperature sensor via interference-free radio signal in the 2.4 GHz frequency range
- Any probe location can be set in LPCplus
- Up to 16 sensors for monitoring at various probe positions
- Guaranteed service life of 100 cycles for the entire sensor
- GMP design of the antenna and sensor
- Fully integrated in the SCADA system
Manometric temperature measurement
MTMplus
The product temperature is one of the most critical parameters in freeze drying. It influences the shape of the ice structure, the speed of the freeze drying process and can initiate the thawing process. The Manometric Temperature Measurement system MTMplus, optimized by Martin Christ, can optimally monitor the temperature.
- The product temperature is online calculated during the measurement
- Non-invasive method
- Reduced risk of product damage
- Easily retrofittable
Loading and unloading systems
Transport your product efficiently and safely. Our Zeta production systems are equipped with automatic loading and unloading systems. We offer you innovative, flexible and customized solutions:
Scale-up
We offer our customers not only state-of-the-art freeze dryers, but also comprehensive project management to increase their production capacities.
With our freeze dryers, scaling up is child's play and we are by your side every step of the way. Let's work together to optimize your production processes and achieve your goals.
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